Plasma-derived exosomal miRNA profiles reveal potential epigenetic pathogenesis of premature ovarian failure
Quick Facts
- Publication title: Plasma-derived exosomal miRNA profiles reveal potential epigenetic pathogenesis of premature ovarian failure
- Journal: Hum Genet
- Year: 2023
- DOI: 10.1007/s00439-023-02618-1
- PMID/PMCID: 38054996; 7487655
Research overview
This study aimed to investigate the epigenetic pathogenesis of POF through exosomal miRNA sequencing. Particularly, hsa-miR-19b-3p emerged as a potential regulator of BMPR2 and demonstrated its functional significance in POF through modulation of apoptosis.
Key findings
The role of plasma-derived exosomal miRNA in premature ovarian failure (POF) remains unclear.
This study aimed to investigate the epigenetic pathogenesis of POF through exosomal miRNA sequencing.
Exosomes were isolated and characterized from six POF patients and four healthy individuals using nanoparticle tracking analysis, transmission electron microscopy and western blot analysis.
Bioinformatics analysis in GSE39501 dataset and our sequencing data was conducted to investigate underlying mechanisms of POF.
Echo Biotech Role
Echo Biotech contributed EV isolation and purification, EV characterization, miRNA profiling/sequencing and bioinformatic analysis.
Related platforms: Exoomics®
Related services and capabilities: Biofluid EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV miRNA Profiling / Sequencing
References
Original publication: Plasma-derived exosomal miRNA profiles reveal potential epigenetic pathogenesis of premature ovarian failure Hum Genet. 2023. DOI: 10.1007/s00439-023-02618-1. PMID/PMCID: 38054996; 7487655.