The potential role of exosomal miRNAs and membrane proteins in acute HIV-infected people
Quick Facts
- Publication title: The potential role of exosomal miRNAs and membrane proteins in acute HIV-infected people
- Journal: Front Immunol
- Year: 2022
- DOI: 10.3389/fimmu.2022.939504
- PMID/PMCID: 36032099; PMC9411714
Research overview
In this study, exosomal miRNAs sequencing and mass cytometry were used to identify differential exosomal miRNAs and membrane proteins that participate in the pathogenesis of TPs and RPs. Yet, information regarding its cargo and its association with HIV rapid progressors (RPs) and typical progressors (TPs) remain largely unknown.
Key findings
Exosomes play an important role during human immunodeficiency virus (HIV) acute infection.
Yet, information regarding its cargo and its association with HIV rapid progressors (RPs) and typical progressors (TPs) remain largely unknown.
In this study, exosomal miRNAs sequencing and mass cytometry were used to identify differential exosomal miRNAs and membrane proteins that participate in the pathogenesis of TPs and RPs.
We discovered that miR-144-5p, miR-1180-3p, miR-451a, miR-362-5p, and miR-625-5p are associated with the TPs and miR-362-5p with the RPs.
Echo Biotech Role
Echo Biotech contributed EV isolation and purification, miRNA profiling/sequencing and bioinformatic analysis; the study also used or cited Exosupur®.
Related platforms: Exoomics®, Research Reagents & Tools
Related services and capabilities: Biofluid EV Isolation & Purification, EV miRNA Profiling / Sequencing, Research Reagent / Product Supply
Related products or reagents: Exosupur® EV Isolation/Purification Kit
References
Original publication: The potential role of exosomal miRNAs and membrane proteins in acute HIV-infected people Front Immunol. 2022. DOI: 10.3389/fimmu.2022.939504. PMID/PMCID: 36032099; PMC9411714.