Profiling expressing features of surface proteins on single-exosome in first-episode Schizophrenia patients: a preliminary study
Quick Facts
- Publication title: Profiling expressing features of surface proteins on single-exosome in first-episode Schizophrenia patients: a preliminary study
- Journal: Schizophrenia
- Year: 2024
- DOI: 10.1038/s41537-024-00510-z
- PMID/PMCID: 39349515; PMC11443124
Research overview
Proximity barcoding assay, a high-throughput method for single-exosome analysis, was employed to profile surface proteins on individual exosomes of SCZ patients. This analysis identified five differentially expressed proteins (DEPs) between SCZ patients and healthy controls (HC) and six DEPs between antipsychotic responders and non-responders.
Key findings
Proximity barcoding assay, a high-throughput method for single-exosome analysis, was employed to profile surface proteins on individual exosomes of SCZ patients.
This analysis identified five differentially expressed proteins (DEPs) between SCZ patients and healthy controls (HC) and six DEPs between antipsychotic responders and non-responders.
Furthermore, two exosome clusters were found to be associated with SCZ, and certain DEPs were correlated with cognitive functions.
Echo Biotech Role
Echo Biotech contributed EV isolation and purification, EV characterization, EV proteomics.
Related platforms: Exoomics®
Related services and capabilities: Biofluid EV Isolation & Purification, EV Basic Characterization (TEM/NTA/WB), EV Proteomics
References
Original publication: Profiling expressing features of surface proteins on single-exosome in first-episode Schizophrenia patients: a preliminary study Schizophrenia. 2024. DOI: 10.1038/s41537-024-00510-z. PMID/PMCID: 39349515; PMC11443124.