Proteomics of Prostate Cancer Tissue Small Extracellular Vesicles Reveal Alteration of Metabolism

Quick Facts

• Publication title: Proteomics of Prostate Cancer Tissue Small Extracellular Vesicles Reveal Alteration of Metabolism
• Journal: Proteomics
• Year: 2025
• DOI: 10.1002/pmic.70081
• PMID/PMCID: 41243699; PMC12976852

Research overview

Leveraging our expertise in murine PCa model establishment and EV isolation from prostate tissue, this study aimed to characterize functional differences between PCa and normal prostate tissue via proteomic analysis of tissue-derived sEVs. These differential proteins in PCa tissue EVs reflect metabolic changes in PCa and may provide insights into the development of early diagnostic biomarkers or novel therapeutic strategies.

Key findings

Prostate cancer (PCa) is a leading male malignancy worldwide, with metabolic reprogramming being a critical hallmark of its progression.

Extracellular vesicles (EVs) derived from tissues directly reflect the tumor microenvironment, offering unique insights into cancer pathophysiology that are unattainable through cell line or biofluid-derived EVs.

However, the functional roles of tissue-derived EVs in PCa metabolism remain poorly understood.

Leveraging our expertise in murine PCa model establishment and EV isolation from prostate tissue, this study aimed to characterize functional differences between PCa and normal prostate tissue via proteomic analysis of tissue-derived sEVs.

Echo Biotech Role

Echo Biotech contributed EV characterization, EV proteomics.

Related platforms: Exoomics®

Related services and capabilities: EV Basic Characterization (TEM/NTA/WB), EV Proteomics

References

Original publication: Proteomics of Prostate Cancer Tissue Small Extracellular Vesicles Reveal Alteration of Metabolism Proteomics. 2025. DOI: 10.1002/pmic.70081. PMID/PMCID: 41243699; PMC12976852.