Single-Vesicle Infrared Nanoscopy for Noninvasive Tumor Malignancy Diagnosis
Quick Facts
- Publication title: Single-Vesicle Infrared Nanoscopy for Noninvasive Tumor Malignancy Diagnosis
- Journal: J Am Chem Soc
- Year: 2022
- DOI: 10.1021/jacs.2c07393
- PMID/PMCID: 36288475
Research overview
We employ near-field infrared (nano-FTIR) spectroscopy to investigate malignancy-related protein heterogeneity in a single sEV and demonstrate the discriminability of sEV protein heterogeneity to evaluate tumor malignancy and metastasis. It provides a noninvasive solution to elucidate cancer development and facilitates the exploitation of potential cancer biomarkers.
Key findings
Protein heterogeneity in molecular expression and structures determines tumorigenesis and is the diagnostic and therapeutic cancer biomarker.
Small extracellular vesicles (sEVs) are cell-released nanoscaled membrane-bound vesicles transferring bioactive molecules for intercellular communication and playing essential roles in tumor progression and metastasis.
Therefore, protein heterogeneity in tumor-derived sEVs indicates the degree of malignant transformation, providing a noninvasive biomarker for cancer diagnosis and malignancy evaluation.
We employ near-field infrared (nano-FTIR) spectroscopy to investigate malignancy-related protein heterogeneity in a single sEV and demonstrate the discriminability of sEV protein heterogeneity to evaluate tumor malignancy and metastasis.
Echo Biotech Role
Echo Biotech contributed EV isolation and purification; the study also used or cited Exosupur®.
Related platforms: Exoomics®, Research Reagents & Tools
Related services and capabilities: Tissue EV Isolation & Purification, Research Reagent / Product Supply
Related products or reagents: Exosupur® EV Isolation/Purification Kit
References
Original publication: Single-Vesicle Infrared Nanoscopy for Noninvasive Tumor Malignancy Diagnosis J Am Chem Soc. 2022. DOI: 10.1021/jacs.2c07393. PMID/PMCID: 36288475.