SPP1 derived from silica-exposed macrophage exosomes triggers fibroblast transdifferentiation
Quick Facts
- Publication title: SPP1 derived from silica-exposed macrophage exosomes triggers fibroblast transdifferentiation
- Journal: Toxicol Appl Pharm
- Year: 2021
- DOI: 10.1016/j.taap.2021.115559
- PMID/PMCID: 33961903
Research overview
To explore the role of exosomal proteins in the occurrence and development of silicosis and the possible intervention targets, this study conducted proteomic analysis of macrophage-derived exosomes induced by silica, to identify specific proteins for intervention. Including inflammatory changes reduced by macrophages and phenotypic transdifferentiation reduced by lung fibroblasts.
Key findings
The occurrence and development of silicosis is related to the interaction of multiple cells through signal transmission caused by silica dust.
Including inflammatory changes reduced by macrophages and phenotypic transdifferentiation reduced by lung fibroblasts.
As a communication medium between cells, exosomes have become a hot research topic.
To explore the role of exosomal proteins in the occurrence and development of silicosis and the possible intervention targets, this study conducted proteomic analysis of macrophage-derived exosomes induced by silica, to identify specific proteins for intervention.
Echo Biotech Role
Echo Biotech contributed EV isolation and purification; the study also used or cited Exosupur®.
Related platforms: Exoomics®, Research Reagents & Tools
Related services and capabilities: EV Isolation & Purification, Research Reagent / Product Supply
Related products or reagents: Exosupur® EV Isolation/Purification Kit
References
Original publication: SPP1 derived from silica-exposed macrophage exosomes triggers fibroblast transdifferentiation Toxicol Appl Pharm. 2021. DOI: 10.1016/j.taap.2021.115559. PMID/PMCID: 33961903.