Targeting delivery of miR-146a via IMTP modified milk exosomes exerted cardioprotective effects by inhibiting NF-κB signaling pathway after myocardial ischemia-reperfusion injury

Quick Facts

  • Publication title: Targeting delivery of miR-146a via IMTP modified milk exosomes exerted cardioprotective effects by inhibiting NF-κB signaling pathway after myocardial ischemia-reperfusion injury
  • Journal: J Nanobiotechnol
  • Year: 2024
  • DOI: 10.1186/s12951-024-02631-0
  • PMID/PMCID: 38951872; PMC11218161

Research overview

In this study, the effects of miR-146a containing MEs (MEs-miR-146a) on improvement of cardiac function were examined in a rat model of MIRI. Taken together, our findings suggested miR-146a containing MEs may be a promising strategy for the treatment of MIRI with better outcome after modification with ischemic myocardium-targeted peptide, which was expected to be applied in clinical practice in future.

Key findings

Reperfusion therapy is critical for saving heart muscle after myocardial infarction, but the process of restoring blood flow can itself exacerbate injury to the myocardium.

This phenomenon is known as myocardial ischemia-reperfusion injury (MIRI), which includes oxidative stress, inflammation, and further cell death.

microRNA-146a (miR-146a) is known to play a significant role in regulating the immune response and inflammation, and has been studied for its potential impact on the improvement of heart function after myocardial injury.

However, the delivery of miR-146a to the heart in a specific and efficient manner remains a challenge as extracellular RNAs are unstable and rapidly degraded.

Echo Biotech Role

Echo Biotech contributed targeting-peptide/surface modification; the study also used or cited ExoBrooch™.

Related platforms: Echosome®, Research Reagents & Tools

Related services and capabilities: Targeting Peptide / Surface Modification, Research Reagent / Product Supply

Related products or reagents: ExoBrooch™ Targeting Peptide/Lipid Anchor Kit

References

Original publication: Targeting delivery of miR-146a via IMTP modified milk exosomes exerted cardioprotective effects by inhibiting NF-κB signaling pathway after myocardial ischemia-reperfusion injury Journal of nanobiotechnology. 2024. DOI: 10.1186/s12951-024-02631-0. PMID/PMCID: 38951872; PMC11218161.