Therapeutic Effects of Simultaneous Delivery of Nerve Growth Factor mRNA and Protein via Exosomes on Cerebral Ischemia
Quick Facts
- Publication title: Therapeutic Effects of Simultaneous Delivery of Nerve Growth Factor mRNA and Protein via Exosomes on Cerebral Ischemia
- Journal: Mol Ther Nucl Acids
- Year: 2020
- DOI: 10.1016/j.omtn.2020.06.013
- PMID/PMCID: 32682291; PMC7365960
Research overview
In this study, we engineered the exosomes with RVG peptide on the surface for neuron targeting and loaded NGF into exosomes simultaneously, with the resultant exosomes denoted as NGF@ExoRVG. Moreover, the strategy proposed in our study may shed light on the clinical application of other neurotrophic factors for central nervous system diseases.
Key findings
Stroke is the leading neurological cause of death and disability all over the world, with few effective drugs.
Nerve growth factor (NGF) is well known for its multifaceted neuroprotective functions post-ischemia.
However, the lack of an efficient approach to systemically deliver bioactive NGF into ischemic region hinders its clinical application.
In this study, we engineered the exosomes with RVG peptide on the surface for neuron targeting and loaded NGF into exosomes simultaneously, with the resultant exosomes denoted as NGF@ExoRVG.
Echo Biotech Role
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References
Original publication: Therapeutic Effects of Simultaneous Delivery of Nerve Growth Factor mRNA and Protein via Exosomes on Cerebral Ischemia Mol Ther Nucl Acids. 2020. DOI: 10.1016/j.omtn.2020.06.013. PMID/PMCID: 32682291; PMC7365960.