Tuberculosis Patients' Serum Extracellular Vesicles Induce Relevant Immune Responses for Initial Defense Against BCG in Mice

Quick Facts

  • Publication title: Tuberculosis Patients' Serum Extracellular Vesicles Induce Relevant Immune Responses for Initial Defense Against BCG in Mice
  • Journal: Microorganisms
  • Year: 2025
  • DOI: 10.3390/microorganisms13071524
  • PMID/PMCID: 40732033; PMC12298580

Research overview

In this study, we collected serum EVs from both healthy individuals and TB patients. This finding also indicates that exploring serum EVs in TB patients with regard to their physiological functions shows excellent potential.

Key findings

Extracellular vesicles (EVs) can be distributed in various bodily fluids, such as serum and urine, and play an essential role in immune regulation, substance transport, and other aspects.

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), which places a tremendous burden on public health prevention and control within society.

Researchers are committed to developing various diagnoses and treatment plans to eliminate TB effectively.

The results of some studies conducted to date demonstrate that the serum EVs of TB patients, which carry components related to Mtb, can be used as relevant markers for TB detection and improve diagnostic efficiency.

Echo Biotech Role

Echo Biotech contributed EV isolation and purification, EV material/reference-material supply; the study also used or cited Exosupur®, ContrExo®.

Related platforms: Exoomics®, EV Materials / Reference Materials, Research Reagents & Tools

Related services and capabilities: EV Re-purification / Free-Dye Removal, EV Material / Reference Material Supply

Related products or reagents: Exosupur® EV Isolation/Purification Kit, ContrExo® EV Reference Material

References

Original publication: Tuberculosis Patients' Serum Extracellular Vesicles Induce Relevant Immune Responses for Initial Defense Against BCG in Mice Microorganisms. 2025. DOI: 10.3390/microorganisms13071524. PMID/PMCID: 40732033; PMC12298580.