Youthful Brain-Derived Extracellular Vesicle-Loaded GelMA Hydrogel Promotes Scarless Wound Healing in Aged Skin by Modulating Senescence and Mitochondrial Function

Quick Facts

  • Publication title: Youthful Brain-Derived Extracellular Vesicle-Loaded GelMA Hydrogel Promotes Scarless Wound Healing in Aged Skin by Modulating Senescence and Mitochondrial Function
  • Journal: Research
  • Year: 2025
  • DOI: 10.34133/research.0644
  • PMID/PMCID: 40161249; PMC11951976

Research overview

In light of this, we identified youthful brain-derived extracellular vesicles (YBEVs) and created a composite GelMA hydrogel material that encourages scarless wound healing in aged skin. In conclusion, the findings suggest that maintaining a youthful brain could potentially alleviate skin aging, and the proposed YBEVs-GelMA hydrogel emerges as a promising strategy for addressing age-related impairments in skin healing.

Key findings

Slow wound healing in the elderly has attracted much attention recently due to the associated infection risks and decreased longevity.

The "brain-skin axis" theory suggests that abnormalities in the brain and nervous system can lead to skin degeneration because abnormal mental states, like chronic stress, can have negative physiological and functional effects on the skin through a variety of processes, resulting in delayed wound healing and accelerated skin aging.

However, it remains unclear whether maintaining a youthful brain has beneficial effects on aged skin healing.

In light of this, we identified youthful brain-derived extracellular vesicles (YBEVs) and created a composite GelMA hydrogel material that encourages scarless wound healing in aged skin.

Echo Biotech Role

Echo Biotech contributed EV proteomics.

Related platforms: Exoomics®

Related services and capabilities: EV Proteomics

References

Original publication: Youthful Brain-Derived Extracellular Vesicle-Loaded GelMA Hydrogel Promotes Scarless Wound Healing in Aged Skin by Modulating Senescence and Mitochondrial Function Research. 2025. DOI: 10.34133/research.0644. PMID/PMCID: 40161249; PMC11951976.